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22 mei 2024 · OpenAlex is a free and open catalog of the global research system that is an index of scholarly works, authors, venues, institutions, and ...
OpenAlex is a free and open catalog of the global research system that is an index of scholarly works, authors, venues, institutions, and concepts. Why use Open Alex for researcher profiles? We use bibliographic metadata and affiliation data from OpenAlex to help power our novel matching system. OpenAlex is extensively...
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Joseph Overton observed that in a given public ... The Overton Window of Political Possibility can help explain these phenomena. ... Free Markets Series · Read more ...
Joseph Overton observed that in a given public policy area, such as education, only a relatively narrow range of potential policies will be considered politically acceptable. This "window" of politically acceptable options is primarily defined not by what politicians prefer, but rather by what they believe they can support and still win re-election.
8. The Levellers | Online Library of Liberty
The Levellers, such as John Lilburne (1615-1657), Richard Overton (1631-1664), and William Walwyn ( ... free trade at a time when virtually none of these ...
The Levellers, such as John Lilburne (1615-1657), Richard Overton (1631-1664), and William Walwyn (c. 1600-1681), were a group of radical libertarian activists and pamphleteers who were active during the English Revolution. They advocated individual liberty, property rights, constitutionally limited government, religious toleration, and free trade at a time when virtually none of these things existed in England. For their troubles, several of them were repeatedly imprisoned and their publications censored. For more information see the main author pages listed below as well as: Topic: the English Revolution School of Thought: 17thC Natural Rights Theorists Historical Debate: the Divine Right of Kings Selected Readings on The English Revolution Tracts on Liberty by the Levellers and their Critics (1638-1660), 7 vols. For more information about our seven volume collection of Leveller Tracts see: Introduction to the Collection Titles Listed by Author Combined Table of Contents (by volume and year) Bibliography The full collection: Tracts on Liberty by the Levellers and their Critics (1638-1660), 7 vols. Edited by David M. Hart and Ross Kenyon (Indianapolis: Liberty Fund, 2014-15). It consists of the following: Vol. 1 (1638-1643) Vol. 2 (1644-1645) Vol. 3 (1646) Vol. 4 (1647) Vol. 5 (1648) Vol. 6 (1649) Vol. 7 (1650-1660) Further Information about the Pamphlets and the Authors Publishing information about each title can be found in the catalog of the George Thomason collection (he...
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10. A deep catalogue of protein-coding variation in 983578 individuals
20 mei 2024 · Rare coding variants that significantly impact function provide insights into the biology of a gene1-3.
Rare coding variants that significantly impact function provide insights into the biology of a gene1-3. However, ascertaining their frequency requires large sample sizes4-8. Here, we present a catalogue of human protein-coding variation, derived from exome sequencing of 983,578 individuals across diverse populations. 23% of the Regeneron Genetics Center Million Exome data (RGC-ME) comes from non-European individuals of African, East Asian, Indigenous American, Middle Eastern, and South Asian ancestry. This catalogue includes over 10.4 million missense and 1.1 million predicted loss-of-function (pLOF) variants. We identify individuals with rare biallelic pLOF variants in 4,848 genes, 1,751 of which have not been previously reported. From precise quantitative estimates of selection against heterozygous loss-of-function, we identify 3,988 loss-of-function intolerant genes, including 86 that were previously assessed as tolerant and 1,153 lacking established disease annotation. We also define regions of missense depletion at high resolution. Notably, 1,482 genes have regions depleted of missense variants despite being tolerant to pLOF variants. Finally, we estimate that 3% of individuals have a clinically actionable genetic variant, and that 11,773 variants reported in ClinVar with unknown significance are likely to be deleterious cryptic splice sites. To facilitate variant interpretation and genetics-informed precision medicine, we make this important resource of coding variation...
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17. The Overton Window : Beck, Glenn : Free Download, Borrow, and ...
26 aug 2020 · Full catalog record: MARCXML · plus-circle Add Review. comment. Reviews. There are no reviews yet. Be the first one to write a review. 140 Views.
xv, 457 pages ; 19 cm
18. Overton
Policy and communications teams · Publishers · Research funders · Think tanks, NGOs and IGOs. Start your free trial. Start a free trial. Follow us on social ...
Is your work influencing policy? We help universities, think tanks and publishers understand the reach and influence of their research Track your policy impact Overton is the world’s largest searchable index of policy documents, guidelines, think tank publications and working papers. It collects data from 188 countries and over a thousand sources worldwide with more […]